Variational multiscale
approaches to biomolecular structure, dynamics and
transport |
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A major feature of biological
science in the 21st Century will be its transition from a phenomenological and
descriptive discipline to a quantitative and predictive one. Revolutionary opportunities have emerged for
mathematically driven advances in biological research. Experimental exploration
of self-organizing biomolecular systems, such as HIV viruses, molecular motors
and proteins in Alzheimer's disease, has been a dominating driven force in
scientific discovery and innovation in the past few decades. However, the emergence of complexity in
self-organizing biological systems poses fundamental challenges to their
quantitative description because of the excessively high dimensionality. This Focus Research Group (FRG) will provide
a platform, led by leading researchers from Universities of Michigan State,
Wisconsin-Madison and Penn State, who will synergistically merge their expertise
in theoretical modeling, scientific computing and mathematical analysis, for
quantitative descriptions of biomolecular systems. The proposed research addresses grand
challenges in the structure, function and dynamics of self-organizing
biomolecular systems due to exceptionally massive data sets. These challenges
are tackled through the introduction of new variational multiscale models,
which reduces the dimensionality and number of degrees of freedom by a
macroscopic continuum description of the aquatic/membrane environment, and a
microscopic discrete description of biomolecules. Additionally, to further
reduce the dimensionality of excessively large biomolecular systems, we
introduce a coarse-grained approach based on the density cluster dynamics which
extracts stable manifolds in molecular dynamics simulations. This FRG project
offers innovative new approaches to the massive data management, dimensionality
reduction, computer simulation, theoretical modeling and mathematical analysis
of biomolecular systems.
This FRG project is a timely
effort to promote the quantitative transition of biological science, which will
lead to emerging new fields in both mathematical and biological sciences. In
particular, the proposed effort will significantly strengthen the leading role
that the US researchers can play in mathematical molecular biosciences by
aggressively pursuing cutting-edge research and collaboratively training a new
generation of mathematicians in this emerging interdisciplinary field. Three annual workshops and international
meeting will be held in Michigan State (Year 1), Wisconsin (Year 2) and Penn
State (Year 3) to strengthen the
collaboration and extend the societal impact.